Products-Tongteng Innovation （Suzhou）Co., Ltd.

Product Number	Product Model	Name
C01.001.001	CEL-G® Culture Ad60	Culture Ad60 Series Fixed Bed Bioreactor Control System, 220V
C01.001.003	BT-2	2㎡ reactor tank
C01.001.002	BT-20	20㎡ reactor tank
C01.001.006	BT-60	60㎡ reactor tank
C01.001.004	FB-2	Consumables for 2㎡ reaction tank
C01.001.005	FB-20	Consumables for 20㎡ reaction tank
C01.001.007	FB-60	Consumables for 60㎡ reaction tank
C01.001.008	Con-U	Aseptic connection lines
C01.001.009	Con-Cap	Aseptic Inoculation / Circulation / Lye / Tail Gas Aseptic Air Barrier System

CEL-G® Culture Ad60 series fixed-bed bioreactors are suitable for large-scale cGMP-grade viral production. The unique technology provides a low-shear 3D culture environment for cell growth, covering the entire process from process parameter development, pilot clinical trials to large-scale commercial production, achieving excellent cell growth and high viral yields. Currently, HEK293 cells are commonly used for the production of viral vectors, which can be classified into adherent culture and suspension culture according to the different culture methods. While adherent cultures are usually difficult to scale up, suspension cultures require cells that can withstand shear disruption. the CEL-G® Culture Ad60 series of fixed-bed bioreactors provide the high specific surface area required for cell growth in a very small footprint, and all sizes of fixed-bed configurations share the same cascade of fluid conditions, covering the process parameter development/pilot clinical validation/large-scale commercial production stages. The overall process has achieved seamless and stable scale-up; the low-shear culture mode and precise regulation of multiple parameters have achieved predictable cell behaviour and steady increase in final yield.

Product Features:

Flexible Configuration

Stainless steel 316L table-top unit suitable for fixed-bed tanks of different sizes.
Effective cell growth area: 2m2, 20m2, 60m2, scale up.
Low footprint and can be used inside a biosafety cabinet.

Efficient Production

Pharmaceutical-grade PET membranes provide a 3D microenvironment for cell growth.
Shear force, gentle and friendly to cells and products.
Dual internal and external circulation allows for batch mode, recirculation mode and perfusion mode.

Precise Control

Flexible and safe sampling for process characterisation.
Powerful in-house algorithms for easy multi-parameter control of the incubation process.
High degree of automation with on-line coupling to downstream processes.

Product Application：

Product Number	Product Model	Name
C01.003.001	FB-2	CEL-G® Culture Ad60 Series 2m2 Reactor Consumables
C01.003.002	FB-20	CEL-G® Culture Ad60 Series 20m2 Reactor Consumables
C01.003.003	FB-60	CEL-G® Culture Ad60 Series 60m2 Reactor Consumables
C01.003.004	Con-U	CEL-G® Culture Ad60 Series Sterile Connections
C01.001.004	Con-Cap	CEL-G® Culture Ad60 Series Aseptic Inoculation / Circulation / Lye / Tail Gas Aseptic Air Barrier System

CEL-G Ad60 固定床生物反应器
案例应用丨CEL-G® Culture Ad60系列固定床生物反应器助力逆转录病毒产量提升
案例应用丨同腾新创CEL-G®系列推动工程化外泌体载药新进展

Ad60 Series Fixed Bed Bioreactors

Overview Parameter Consumables Resources COA